Renegade Indians have been on the rampage attacking settlers and raising havoc in the West. Joe and Hoss have gone to warn the settlers when Joe is shot with an arrow. Hoss tries to remove the arrow, but the shaft breaks and it is imbedded in Joe’s shoulder, leaving Joe gravely wounded. Hoss desperately searches for help and comes upon a wagon train with an odd assortment of people. There are two women, a thief, a dying doctor, and a coward on the wagon train.